Assistant Professor


Curriculum vitae



Department of Obstetrics and Gynecology

Department of Health Research Methods, Evidence and Impact

McMaster University
1280 Main St. West,
HSC3V - 43B
Hamilton, Ontario ​L8S 4K1
Canada



Neonatal abstinence syndrome and infant mortality and morbidity: a population-based study


Journal article


Sarka Lisonkova, Qi Wen, Lindsay L Richter, Joseph Y Ting, Janet Lyons, Sheona Mitchell-Foster, Eugenia Oviedo-Joekes, Giulia M Muraca, Hamideh Bayrampour, Eric Cattoni, Ronald Abrahams
Frontiers in Pediatrics, vol. 12, 2024, p. 1394682


Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Lisonkova, S., Wen, Q., Richter, L. L., Ting, J. Y., Lyons, J., Mitchell-Foster, S., … Abrahams, R. (2024). Neonatal abstinence syndrome and infant mortality and morbidity: a population-based study. Frontiers in Pediatrics, 12, 1394682. https://doi.org/10.3389/fped.2024.1394682


Chicago/Turabian   Click to copy
Lisonkova, Sarka, Qi Wen, Lindsay L Richter, Joseph Y Ting, Janet Lyons, Sheona Mitchell-Foster, Eugenia Oviedo-Joekes, et al. “Neonatal Abstinence Syndrome and Infant Mortality and Morbidity: a Population-Based Study.” Frontiers in Pediatrics 12 (2024): 1394682.


MLA   Click to copy
Lisonkova, Sarka, et al. “Neonatal Abstinence Syndrome and Infant Mortality and Morbidity: a Population-Based Study.” Frontiers in Pediatrics, vol. 12, 2024, p. 1394682, doi:10.3389/fped.2024.1394682.


BibTeX   Click to copy

@article{sarka2024a,
  title = {Neonatal abstinence syndrome and infant mortality and morbidity: a population-based study},
  year = {2024},
  journal = {Frontiers in Pediatrics},
  pages = {1394682},
  volume = {12},
  doi = {10.3389/fped.2024.1394682},
  author = {Lisonkova, Sarka and Wen, Qi and Richter, Lindsay L and Ting, Joseph Y and Lyons, Janet and Mitchell-Foster, Sheona and Oviedo-Joekes, Eugenia and Muraca, Giulia M and Bayrampour, Hamideh and Cattoni, Eric and Abrahams, Ronald}
}

Abstract

Background Infant health among newborns with neonatal abstinence syndrome (NAS) has been understudied. We examined infant mortality and hospitalizations among infants diagnosed with NAS after birth. Methods All live births in British Columbia (BC), Canada, for fiscal years from 2004–2005 to 2019–2020, were included (N = 696,900). NAS was identified based on International Classification of Diseases, version 10, Canadian modification (ICD-10-CA) codes; the outcomes included infant death and hospitalizations during the first year of life, ascertained from BC linked administrative data. Generalized estimating equation models were used to adjust for maternal factors. Results There were 2,439 infants with NAS (3.50 per 1,000 live births). Unadjusted for other factors, infant mortality was 2.5-fold higher in infants with vs. without NAS (7.79 vs. 3.08 per 1,000 live births, respectively) due to increased post-discharge mortality NAS (5.76 vs. 1.34 per 1,000 surviving infants, respectively). These differences diminished after adjustment: adjusted odds ratio (AOR) for infant death was 0.85 [95% confidence interval (CI): 0.52–1.39]; AOR for post-discharge death was 1.75 (95% CI 1.00–3.06). Overall, 22.3% infants with NAS had at least one hospitalization after post-neonatal discharge, this proportion was 10.7% in those without NAS. During the study period, discharge to foster care declined from 49.5% to 20.3% in infants with NAS. Conclusion Unadjusted for other factors, infants with NAS had increased post-discharge infant mortality and hospitalizations during the first year of life. This association diminished after adjustment for adverse maternal and socio-medical conditions. Infants with NAS had a disproportionately higher rate of placement in foster care after birth, although this proportion declined dramatically between 2004/2005 and 2019/2020. These results highlight the importance of implementing integrated care services to support infants born with NAS and their mothers during the first year of life and beyond, even though NAS itself is not independently associated with increased infant mortality.


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