Journal article
Annals of Surgery, 10.1097, 2024
Assistant Professor
Department of Obstetrics and Gynecology
Department of Health Research Methods, Evidence and Impact
McMaster University
1280 Main St. West,
HSC3V - 43B
Hamilton, Ontario L8S 4K1
Canada
APA
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Doumouras, A. G., Muraca, G. M., Darling, E. K., O’Callaghan, E. K., Nguyen, F., Boudreau, V., & Anvari, M. (2024). Maternal, fetal and infant outcomes associated with bariatric surgery: A matched cohort study. Annals of Surgery, 10.1097. https://doi.org/10.1097/SLA.0000000000006536
Chicago/Turabian
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Doumouras, Aristithes G, Giulia M Muraca, Elizabeth K Darling, Emma K O’Callaghan, Francis Nguyen, Vanessa Boudreau, and Mehran Anvari. “Maternal, Fetal and Infant Outcomes Associated with Bariatric Surgery: A Matched Cohort Study.” Annals of Surgery 10.1097 (2024).
MLA
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Doumouras, Aristithes G., et al. “Maternal, Fetal and Infant Outcomes Associated with Bariatric Surgery: A Matched Cohort Study.” Annals of Surgery, vol. 10.1097, 2024, doi:10.1097/SLA.0000000000006536.
BibTeX Click to copy
@article{aristithes2024a,
title = {Maternal, fetal and infant outcomes associated with bariatric surgery: A matched cohort study},
year = {2024},
journal = {Annals of Surgery},
volume = {10.1097},
doi = {10.1097/SLA.0000000000006536},
author = {Doumouras, Aristithes G and Muraca, Giulia M and Darling, Elizabeth K and O’Callaghan, Emma K and Nguyen, Francis and Boudreau, Vanessa and Anvari, Mehran}
}
The purpose of this study was to determine the association between bariatric surgery and maternal, fetal and infant outcomes.
Obesity during pregnancy is a risk factor for adverse pregnancy outcomes. Bariatric surgery is the most effective weight loss treatment but the impact of bariatric surgery on pregnancy outcomes remains poorly characterised.
This was a population-based, matched cohort study of prospective databases in Ontario, Canada. Patients with obesity who received bariatric surgery from 2010 to 2016 and subsequently became pregnant matched on multiple factors to non-surgical pregnant patients with obesity. The primary outcomes of interest were the incidence included of gestational diabetes, preeclampsia/HELLP syndrome, small for gestational age (SGA), large for gestational age (LGA), and a composite of severe fetal/infant morbidity/mortality. Multivariable regression evaluated outcomes.
680 patients who underwent bariatric surgery and later became pregnant were matched to 2002 pregnant patients with obesity. Gestational diabetes occurred in 8.7% of the surgery group and 18.8% of the non-surgical group (adjusted OR (aOR) 0.29, 95%CI 0.21-0.40, P<0.001). A lower incidence of preeclampsia/HELLP was observed post-surgery (aOR 0.20, 95%CI 0.13-0.31, P<0.001). Bariatric surgery impacted SGA (aOR 2.74, 95%CI 2.04–3.70, P<0.001) and LGA (aOR 0.25, 95%CI 0.18-0.36, P<0.001). There were no observed associations between bariatric surgery and any adverse fetal or infant outcomes. A lower composite severe fetal/infant morbidity/mortality was observed post-surgery (aOR 0.73, 95%CI 0.54-0.97, P<0.05).
Pregnancy after bariatric surgery appears safe and was associated with a reduced risk of several obesity related adverse pregnancy outcomes.